Product Datasheet  
SIN3B Antibody  
Catalog Number: 33607  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: O75182
    NCBI Gene ID: 23309
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from internal of human SIN3B.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

    Immunofluorescence: 1:100~1:500
  • other_names：  
  • Paired amphipathic helix protein Sin3b; Transcriptional corepressor Sin3b; Histone deacetylase complex subunit Sin3b; SIN3B; KIAA0700
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total SIN3B protein.
  • Applications：  
  • WB IF
  • Background：  
  • Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription By similarity.

    Ishikawa K., DNA Res. 5:169-176(1998).
    The MGC Project Team, Genome Res. 14:2121-2127(2004).
    Wysocka J., Genes Dev. 17:896-911(2003).



 
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