XPA Antibody

Catalog Number:

33544

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P23025
NCBI Gene ID: 7507

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human XPA.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total XPA protein.

Applications:

WB IHC

Background:

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.

Gary W. Daughdrill, Nucleic Acids Res., Jul 2003; 31: 4176 - 4183.
Esther M. Hoogervorst, Carcinogenesis, Mar 2003; 24: 613 - 619.
Karen M. Vasquez, PNAS, Apr 2002; 99: 5848.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF