Product Datasheet  
XPA Antibody  
Catalog Number: 33544  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P23025
    NCBI Gene ID: 7507
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human XPA.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • DNA-repair protein complementing XP-A cells; XPAC; Xeroderma pigmentosum group A complementing protein;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total XPA protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.

    Gary W. Daughdrill, Nucleic Acids Res., Jul 2003; 31: 4176 - 4183.
    Esther M. Hoogervorst, Carcinogenesis, Mar 2003; 24: 613 - 619.
    Karen M. Vasquez, PNAS, Apr 2002; 99: 5848.



 
© Signalway Biotechnology All Rights Reserved.