TNF Receptor-1 Antibody

Catalog Number:

33527

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P19438
NCBI Gene ID: 7132

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human TNF receptor-1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total TNF receptor-1 protein.

Applications:

IHC

Background:

Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

Jennifer Adjodha, AACR Meeting Abstracts, Apr 2006; 2006: 1028.
Kewu Huang, J Appl Physiol, Apr 2007; 102: 1632 - 1639.
Kiyoshi Asada, AACR Meeting Abstracts, Apr 2005; 2005: 202.
Elaine K Green, J. Med. Genet., Aug 2000; 37: 581.

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF