Product Datasheet  
TNF Receptor-1 Antibody  
Catalog Number: 33527  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P19438
    NCBI Gene ID: 7132
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from Internal of human TNF receptor-1.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100
  • other_names：  
  • CD120a; TBPI; TNF-RI; TNFAR; TNFR1
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total TNF receptor-1 protein.
  • Applications：  
  • IHC
  • Background：  
  • Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

    Jennifer Adjodha, AACR Meeting Abstracts, Apr 2006; 2006: 1028.
    Kewu Huang, J Appl Physiol, Apr 2007; 102: 1632 - 1639.
    Kiyoshi Asada, AACR Meeting Abstracts, Apr 2005; 2005: 202.
    Elaine K Green, J. Med. Genet., Aug 2000; 37: 581.



 
© Signalway Biotechnology All Rights Reserved.