NYREN18 Antibody

Catalog Number:

33514

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9Y5A7
NCBI Gene ID: 51667

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human NYREN18.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NYREN18 protein.

Applications:

WB IHC

Background:

Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.

Sarah M. Mense, Toxicol. Sci., Sep 2006; 93: 125 - 135.
Gunter Schmidtke, J. Biol. Chem., Jul 2006; 281: 20045 - 20054.s
Kunikazu Tanji, Am. J. Pathol., Aug 2006; 169: 553 - 565.
Miguel Ramalho-Santos, Science, Oct 2002; 298: 597.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF