Product Datasheet  
NYREN18 Antibody  
Catalog Number: 33514  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9Y5A7
    NCBI Gene ID: 51667
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from C-terminal of human NYREN18.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • NEDD8 ultimate buster-1; NUB1; NY-REN-18 antigen;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total NYREN18 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2.

    Sarah M. Mense, Toxicol. Sci., Sep 2006; 93: 125 - 135.
    Gunter Schmidtke, J. Biol. Chem., Jul 2006; 281: 20045 - 20054.s
    Kunikazu Tanji, Am. J. Pathol., Aug 2006; 169: 553 - 565.
    Miguel Ramalho-Santos, Science, Oct 2002; 298: 597.



 
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