Synuclein β Antibody

Catalog Number:

33494

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q16143
NCBI Gene ID: 6620

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Synuclein β antibody.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Synuclein β protein.

Applications:

WB IHC IF

Background:

Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

Yuxin Fan, Hum. Mol. Genet., Oct 2006; 15: 3002 - 3011.
Makoto Hashimoto, J. Biol. Chem., May 2004; 279: 23622 - 23629.
Cristine Alves da Costa, J. Biol. Chem., Sep 2003; 278: 37330 - 37335.
Heather Snyder, J. Biol. Chem., Mar 2005; 280: 7562 - 7569.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF