Product Datasheet  
Synuclein β Antibody  
Catalog Number: 33494  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q16143
    NCBI Gene ID: 6620
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Synuclein β antibody.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
    Immunofluorescence: 1:100~1:500
  • other_names：  
  • SYUB; beta-synuclein;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Synuclein β protein.
  • Applications：  
  • WB IHC IF
  • Background：  
  • Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

    Yuxin Fan, Hum. Mol. Genet., Oct 2006; 15: 3002 - 3011.
    Makoto Hashimoto, J. Biol. Chem., May 2004; 279: 23622 - 23629.
    Cristine Alves da Costa, J. Biol. Chem., Sep 2003; 278: 37330 - 37335.
    Heather Snyder, J. Biol. Chem., Mar 2005; 280: 7562 - 7569.



 
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