Sodium Channel-pan Antibody

Catalog Number:

33488

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q14524
NCBI Gene ID: 6323/6326/6328/6329/6331/6334/6335/6336/11280

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human sodium channel.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total sodium channel protein.

Applications:

WB IHC

Background:

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.

Sebastian K.G. Maier, Circulation, Mar 2004; 109: 1421 - 1427.
T.R. Cummins, Neurology, Jan 2003; 60: 224 - 229.
Christopher A. Ahern, Circ. Res., May 2005; 96: 991 - 998.
Jyoti Dhar Malhotra, Circulation, Mar 2001; 103: 1303 - 1310.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF