Product Datasheet  
Sodium Channel-pan Antibody  
Catalog Number: 33488  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q14524
    NCBI Gene ID: 6323/6326/6328/6329/6331/6334/6335/6336/11280
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human sodium channel.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • CIN5; HH1; SCN5A; Sodium channel protein; cardiac muscle alpha-subunit
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total sodium channel protein.
  • Applications：  
  • WB IHC
  • Background：  
  • This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.

    Sebastian K.G. Maier, Circulation, Mar 2004; 109: 1421 - 1427.
    T.R. Cummins, Neurology, Jan 2003; 60: 224 - 229.
    Christopher A. Ahern, Circ. Res., May 2005; 96: 991 - 998.
    Jyoti Dhar Malhotra, Circulation, Mar 2001; 103: 1303 - 1310.




 
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