SH-PTP2 Antibody

Catalog Number:

33485

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q06124
NCBI Gene ID: 5781

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human SH-PTP2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total SH-PTP2 protein.

Applications:

WB IHC

Background:

Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

T Noguchi, Mol. Cell. Biol., Oct 1994; 14: 6674 - 6682.
U Dechert, J. Biol. Chem., Feb 1994; 269: 5602 - 5611.
Hiroshi Ohnishi, J. Biol. Chem., Oct 1996; 271: 25569.
Tetsuya Noguchi, J. Biol. Chem., Nov 1996; 271: 27652.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF