Product Datasheet  
SH-PTP2 Antibody  
Catalog Number: 33485  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q06124
    NCBI Gene ID: 5781
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human SH-PTP2.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total SH-PTP2 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity.

    T Noguchi, Mol. Cell. Biol., Oct 1994; 14: 6674 - 6682.
    U Dechert, J. Biol. Chem., Feb 1994; 269: 5602 - 5611.
    Hiroshi Ohnishi, J. Biol. Chem., Oct 1996; 271: 25569.
    Tetsuya Noguchi, J. Biol. Chem., Nov 1996; 271: 27652.




 
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