RCC1 Antibody

Catalog Number:

33479

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P18754
NCBI Gene ID: 55213

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human RCC1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total RCC1 protein.

Applications:

WB IHC

Background:

Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.

M Dasso, Mol. Cell. Biol., Aug 1992; 12: 3337 - 3345.
Hoi Yeung Li, J. Cell Biol., Mar 2003; 160: 635.
Michael E. Nemergut, Science, May 2001; 292: 1540.
Ian Cushman, Mol. Biol. Cell, Jan 2004; 15: 245.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF