Product Datasheet  
RCC1 Antibody  
Catalog Number: 33479  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P18754
    NCBI Gene ID: 55213
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human RCC1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • CHC1; Cell cycle regulatory protein; Regulator of chromosome condensation;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total RCC1 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.

    M Dasso, Mol. Cell. Biol., Aug 1992; 12: 3337 - 3345.
    Hoi Yeung Li, J. Cell Biol., Mar 2003; 160: 635.
    Michael E. Nemergut, Science, May 2001; 292: 1540.
    Ian Cushman, Mol. Biol. Cell, Jan 2004; 15: 245.




 
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