Patched Antibody

Catalog Number:

33466

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q13635
NCBI Gene ID: 5727

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Patched.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Patched protein.

Applications:

WB IHC

Background:

Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

Trudy G. Oliver, Development, May 2005; 132: 2425 - 2439.
Florence Brellier, Cancer Res., Apr 2004; 64: 2699 - 2704.
Heidi Hahn, J. Biol. Chem., May 1996; 271: 12125.
RL Johnson, Development, Dec 1995; 121: 4161.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF