Product Datasheet  
Patched Antibody  
Catalog Number: 33466  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q13635
    NCBI Gene ID: 5727
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Patched.
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • DROSOPHILA HOMOLOG OF 1; patched homolog (Drosophila);
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Patched protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

    Trudy G. Oliver, Development, May 2005; 132: 2425 - 2439.
    Florence Brellier, Cancer Res., Apr 2004; 64: 2699 - 2704.
    Heidi Hahn, J. Biol. Chem., May 1996; 271: 12125.
    RL Johnson, Development, Dec 1995; 121: 4161.




 
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