Cyclin-L1 Antibody

Catalog Number:

33465

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UK58
NCBI Gene ID: 57018

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Cyclin-L1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Cyclin-L1 protein.

Applications:

WB IHC

Background:

Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.

A. Hamid Boulares, J. Biol. Chem., Aug 1999; 274: 22932.
Alessandra Pagano, Am J Physiol Lung Cell Mol Physiol, Jun 2007; 10.1152.
Mi Young Kim, Genes & Dev., Sep 2005; 19: 1951 - 1967.
Silke S¨¹sse, Nucleic Acids Res., Feb 2004; 32: 669 - 680.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF