Product Datasheet  
Cyclin-L1 Antibody  
Catalog Number: 33465  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9UK58
    NCBI Gene ID: 57018
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Cyclin-L1.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Cyclin-L; CCNL1;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Cyclin-L1 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Transcriptional regulator which participates in regulating the pre-mRNA splicing process. Seems to be involved in the regulation of RNA polymerase II (pol II). Functions in association with cyclin-dependent kinases (CDKs) and has a role in the second step of splicing. May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC). Inhibited by the CDK-specific inhibitor p21.

    A. Hamid Boulares, J. Biol. Chem., Aug 1999; 274: 22932.
    Alessandra Pagano, Am J Physiol Lung Cell Mol Physiol, Jun 2007; 10.1152.
    Mi Young Kim, Genes & Dev., Sep 2005; 19: 1951 - 1967.
    Silke S¨¹sse, Nucleic Acids Res., Feb 2004; 32: 669 - 680.




 
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