NRF2 Antibody

Catalog Number:

33450

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q16236
NCBI Gene ID: 4780

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human NRF2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NRF2 protein.

Applications:

WB IHC IF

Background:

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Rajesh K. Thimmulappa, J. Clin. Invest., Apr 2006; 116: 984 - 995.
Sara B. Cullinan, Mol. Cell. Biol., Oct 2003; 23: 7198 - 7209.
Tirumalai Rangasamy, J. Exp. Med., Jul 2005; 202: 47 - 59.
Wenge Li, J. Biol. Chem., Aug 2005; 280: 28430 - 28438.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF