NKX3.1 Antibody

Catalog Number:

33448

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q99801
NCBI Gene ID: 4824

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from N-terminal of human NKX3.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NKX3.1 protein.

Applications:

IHC

Background:

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Cai Bowen, Cancer Res., Jan 2007; 67: 455 - 464.
Xiang Li, Mol. Cell. Biol., Apr 2006; 26: 3008 - 3017.
Ekatherine Asatiani, Cancer Res., Feb 2005; 65: 1164 - 1173.
Carlise R. Bethel, Cancer Res., Nov 2006; 66: 10683 - 10690.

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF