Product Datasheet  
NKX3.1 Antibody  
Catalog Number: 33448  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q99801
    NCBI Gene ID: 4824
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from N-terminal of human NKX3.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100
  • other_names：  
  • Homeobox protein Nkx-3.1; NKX31; NKX3A;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total NKX3.1 protein.
  • Applications：  
  • IHC
  • Background：  
  • Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

    Cai Bowen, Cancer Res., Jan 2007; 67: 455 - 464.
    Xiang Li, Mol. Cell. Biol., Apr 2006; 26: 3008 - 3017.
    Ekatherine Asatiani, Cancer Res., Feb 2005; 65: 1164 - 1173.
    Carlise R. Bethel, Cancer Res., Nov 2006; 66: 10683 - 10690.



 
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