NCK2 Antibody

Catalog Number:

33447

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O43639
NCBI Gene ID: 8440

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from C-terminal of human NCK2.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total NCK2 protein.

Applications:

IHC

Background:

Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.

Susanne Frese, J. Biol. Chem., Jun 2006; 281: 18236 - 18245.
Friedhelm Bladt, Mol. Cell. Biol., Jul 2003; 23: 4586 - 4597.
Stephan J. Kempiak, J. Biol. Chem., Feb 2005; 280: 5836 - 5842.
Min Chen, Mol. Cell. Biol., Nov 2000; 20: 7867 - 7880.

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF