MMP-16 Antibody

Catalog Number:

33439

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P51512
NCBI Gene ID: 4325

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human MMP-16 antibody.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MMP-16 protein.

Applications:

WB IHC

Background:

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform shortcleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

S. Simsa, J Anim Sci, Jun 2007; 85: 1393 - 1401.
Dong-Jin Oh, Invest. Ophthalmol. Vis. Sci., Sep 2006; 47: 3887 - 3895.
Amit Bar-Or, Brain, Dec 2003; 126: 2738 - 2749.
Marco Seandel, Blood, Apr 2001; 97: 2323 - 2332.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF