MMP-14 Antibody

Catalog Number:

33437

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P50281
NCBI Gene ID: 4323

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human MMP-14.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total MMP-14 protein.

Applications:

WB IHC

Background:

Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.

Bimal K. Ray, Circ. Res., Nov 2004; 95: 1082 - 1090.
Sharon Elliot, Invest. Ophthalmol. Vis. Sci., Apr 2006; 47: 1696 - 1702.
Hongqing Q. Ye, Invest. Ophthalmol. Vis. Sci., Sep 2000; 41: 2894.
Leanne J. Bakke, Biol Reprod, Jun 2002; 66: 1627.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF