Product Datasheet  
MMP-14 Antibody  
Catalog Number: 33437  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P50281
    NCBI Gene ID: 4323
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human MMP-14.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • MT1-MMP; MATRIX METALLOPROTEINASE 14; MEMBRANE-TYPE; MEMBRANE-TYPE MATRIX METALLOPROTEINASE 1; matrix metalloproteinase 14 (membrane-inserted).
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total MMP-14 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.

    Bimal K. Ray, Circ. Res., Nov 2004; 95: 1082 - 1090.
    Sharon Elliot, Invest. Ophthalmol. Vis. Sci., Apr 2006; 47: 1696 - 1702.
    Hongqing Q. Ye, Invest. Ophthalmol. Vis. Sci., Sep 2000; 41: 2894.
    Leanne J. Bakke, Biol Reprod, Jun 2002; 66: 1627.




 
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