Fibrillin-1 Antibody

Catalog Number:

33375

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P35555
NCBI Gene ID: 2200

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Fibrillin-1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Fibrillin-1 protein.

Applications:

IHC

Background:

Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

Ehab El-Hallous, J. Biol. Chem., Mar 2007; 282: 8935 - 8946.
Shazia S. Chaudhry, J. Cell Biol., Jan 2007; 176: 355 - 367.
Kerstin Tiedemann, J. Biol. Chem., Sep 2001; 276: 36035 - 36042.
Liliana Schaefer, Am. J. Pathol., Aug 2004; 165: 383 - 396.

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF