Product Datasheet  
Fibrillin-1 Antibody  
Catalog Number: 33375  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P35555
    NCBI Gene ID: 2200
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Fibrillin-1.
  • reactivity：  
  • Hu
  • appl_detail：  

  • Immunohistochemistry: 1:50~1:100
  • other_names：  
  • MASS; MFS1; OCTD; SGS; WMS
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Fibrillin-1 protein.
  • Applications：  
  • IHC
  • Background：  
  • Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively.

    Ehab El-Hallous, J. Biol. Chem., Mar 2007; 282: 8935 - 8946.
    Shazia S. Chaudhry, J. Cell Biol., Jan 2007; 176: 355 - 367.
    Kerstin Tiedemann, J. Biol. Chem., Sep 2001; 276: 36035 - 36042.
    Liliana Schaefer, Am. J. Pathol., Aug 2004; 165: 383 - 396.



 
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