DP-1 Antibody

Catalog Number:

33359

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q14186
NCBI Gene ID: 7027

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human DP-1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total DP-1 protein.

Applications:

WB IHC IF

Background:

Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis.

K Helin, Genes & Dev., Oct 1993; 7: 1850 - 1861.
B Shan, Cell Growth Differ., Jun 1996; 7: 689.
Hironori Ishida, J. Biol. Chem., Jul 2005; 280: 24642 - 24648.
Wing Y. Chang, J. Biol. Chem., Dec 2004; 279: 51343 - 51353.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF