Cox1 Antibody

Catalog Number:

33344

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P23219
NCBI Gene ID: 5742

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human COX1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total COX1 protein.

Applications:

WB IHC

Background:

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

Lawrence M. Szewczuk, J. Biol. Chem., May 2004; 279: 22727 - 22737.
Syed R. Baber, Am J Physiol Heart Circ Physiol, Oct 2005; 289: H1476 - H1487.
Subhashini Chandrasekharan, J. Lipid Res., Dec 2005; 46: 2636 - 2648.
K. Trent Moreland, J. Pharmacol. Exp. T

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF