Product Datasheet  
Cox1 Antibody  
Catalog Number: 33344  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P23219
    NCBI Gene ID: 5742
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human COX1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
  • other_names：  
  • COX3; PCOX1; CYCLOOXYGENASE 1; PARTIAL COX1 PROTEINS; PGHS1 CYCLOOXYGENASE 3
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total COX1 protein.
  • Applications：  
  • WB IHC
  • Background：  
  • Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

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    Syed R. Baber, Am J Physiol Heart Circ Physiol, Oct 2005; 289: H1476 - H1487.
    Subhashini Chandrasekharan, J. Lipid Res., Dec 2005; 46: 2636 - 2648.
    K. Trent Moreland, J. Pharmacol. Exp. T



 
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