Connexin 43 Antibody

Catalog Number:

33343

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P17302
NCBI Gene ID: 2697

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Connexin 43.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Connexin 43 protein.

Applications:

WB IHC IF

Background:

Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract By similarity.

Toshihiko Toyofuku, J. Biol. Chem., May 1998; 273: 12725.
Toshihiko Toyofuku, J. Biol. Chem., Jan 1998; 273: 1519.
Masayuki Shimada, Biol Reprod, Apr 2001; 64: 1255.
Merry L. Lindsey, Circulation, Jun 2006; 113: 2919 - 2928.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF