Product Datasheet  
Connexin 43 Antibody  
Catalog Number: 33343  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P17302
    NCBI Gene ID: 2697
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Connexin 43.
  • reactivity：  
  • Hu Ms Rt
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
    Immunofluorescence: 1:100~1:500
  • other_names：  
  • CX43; CXA1; CXN-43; GJA1; Gap junction 43 kDa heart protein
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Connexin 43 protein.
  • Applications：  
  • WB IHC IF
  • Background：  
  • Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract By similarity.

    Toshihiko Toyofuku, J. Biol. Chem., May 1998; 273: 12725.
    Toshihiko Toyofuku, J. Biol. Chem., Jan 1998; 273: 1519.
    Masayuki Shimada, Biol Reprod, Apr 2001; 64: 1255.
    Merry L. Lindsey, Circulation, Jun 2006; 113: 2919 - 2928.



 
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