Caveolin-1 Antibody

Catalog Number:

33331

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q03135
NCBI Gene ID: 857

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from human Caveolin-1.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Caveolin-1 protein.

Applications:

WB IF

Background:

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

Wei Zhang, J. Biol. Chem., Jun 2000; 275: 20717.
Rosalia Mora, J. Biol. Chem., Sep 1999; 274: 25708.
Isabella Parolini, J. Biol. Chem., Sep 1999; 274: 25718.
Phuong U. Le, J. Biol. Chem., Jan 2002; 277: 3371 - 3379.

References:

appl_detail:

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Datasheet PDF