Product Datasheet  
Caveolin-1 Antibody  
Catalog Number: 33331  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q03135
    NCBI Gene ID: 857
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized peptide derived from human Caveolin-1.
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000

    Immunofluorescence: 1:100~1:500
  • other_names：  
  • CAV; CAV1; MSTP085; VIP21; caveolae protein
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Caveolin-1 protein.
  • Applications：  
  • WB IF
  • Background：  
  • May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity By similarity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.

    Wei Zhang, J. Biol. Chem., Jun 2000; 275: 20717.
    Rosalia Mora, J. Biol. Chem., Sep 1999; 274: 25708.
    Isabella Parolini, J. Biol. Chem., Sep 1999; 274: 25718.
    Phuong U. Le, J. Biol. Chem., Jan 2002; 277: 3371 - 3379.



 
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