APLP2 (Ab-755) Antibody

Catalog Number:

33274

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q06481
NCBI Gene ID: 334

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human APLP2 around the phosphorylation site of tyrosine 755 (P-T-Y(p)-K-Y).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total APLP2 protein.

Applications:

WB

Background:

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts By similarity.

Sprecher C.A., Biochemistry 32:4481-4486(1993).
Wasco W., Nat. Genet. 5:95-99(1993).
von der Kammer H., DNA Cell Biol. 13:1137-1143(1994).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF