GAB2 (Ab-159) Antibody

Catalog Number:

33262

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UQC2
NCBI Gene ID: 9846

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human GAB2 around the phosphorylation site of serine 159 (K-S-S(p)-A-P).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total GAB2 protein.

Applications:

WB IHC

Background:

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Nishida K., Blood 93:1809-1816(1999).
Nagase T., DNA Res. 5:31-39(1998).
Taylor T.D., Nature 440:497-500(2006).

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF