Product Datasheet  
GAB2 (Ab-159) Antibody  
Catalog Number: 33262  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: Q9UQC2
    NCBI Gene ID: 9846
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized non-phosphopeptide derived from human GAB2 around the phosphorylation site of serine 159 (K-S-S(p)-A-P).
  • reactivity：  
  • Hu
  • appl_detail：  

  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100

  • other_names：  
  • GABJ; GRB2-associated binding protein 2; KIAA0571; pp100;
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total GAB2 protein.
  • Applications：  
  • WB IHC
  • Background：  

  • Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

    Nishida K., Blood 93:1809-1816(1999).
    Nagase T., DNA Res. 5:31-39(1998).
    Taylor T.D., Nature 440:497-500(2006).




 
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