Vitamin D3 Receptor (Ab-51) Antibody

Catalog Number:

33256

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P11473
NCBI Gene ID: 7421

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human Vitamin D3 Receptor around the phosphorylation site of serine 51 (R-R-S(p)-M-K).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Vitamin D3 Receptor protein.

Applications:

WB

Background:

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

Baker A.R., Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).
Goto H., Biochim. Biophys. Acta 1132:103-108(1992).
Miyamoto K., Mol. Endocrinol. 11:1165-1179(1997).

References:

appl_detail:

Western blotting: 1:500~1:3000

Datasheet PDF