Product Datasheet  
Vitamin D3 Receptor (Ab-51) Antibody  
Catalog Number: 33256  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P11473
    NCBI Gene ID: 7421
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized non-phosphopeptide derived from human Vitamin D3 Receptor around the phosphorylation site of serine 51 (R-R-S(p)-M-K).
  • reactivity：  
  • Hu Ms
  • appl_detail：  
  • Western blotting: 1:500~1:3000

  • other_names：  
  • 1,25-dihydroxyvitamin D3 receptor; NR1I1; vitamin D receptor; vitamin D3 receptor
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total Vitamin D3 Receptor protein.
  • Applications：  
  • WB
  • Background：  
  • Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.

    Baker A.R., Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).
    Goto H., Biochim. Biophys. Acta 1132:103-108(1992).
    Miyamoto K., Mol. Endocrinol. 11:1165-1179(1997).



 
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