p73 Antibody

Catalog Number:

33579

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: O15350
NCBI Gene ID: 7161

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from internal of human p73.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total p73 protein.

Applications:

WB IHC

Background:

Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.

Kaghad M., Cell 90:809-819(1997).
Mai M., Genomics 51:359-363(1998).
De Laurenzi V., J. Exp. Med. 188:1763-1768(1998).

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100

Datasheet PDF