Histone H2A Antibody

Catalog Number:

33265

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P0C0S8/P04908/P20671/Q96KK5/Q6FI13/Q7L7L0
NCBI Gene ID: 8329/8332/8336/8969/3012/8335/3013/85235/723790/8337/92815

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized peptide derived from Internal of human Histone H2A.

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total Histone H2A protein.

Applications:

IHC

Background:

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Albig W., Hum. Genet. 101:284-294(1997).
Albig W., Biol. Chem. 380:7-18(1999).
Dobner T., DNA Seq. 1:409-413(1991).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF