HSP90B (Ab-254) Antibody

Catalog Number:

33117

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P08238
NCBI Gene ID: 3326

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Synthesized non-phosphopeptide derived from human HSP90B around the phosphorylation site of serine 254 (V-G-S(p)-D-E).

Purification:

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Specificity/Sensitivity:

The antibody detects endogenous levels of total HSP90B protein.

Applications:

WB IHC IF

Background:

Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Lothar Goretzki, AACR Meeting Abstracts, Apr 2006; 2006: 468.
Jean-Fran?ois Louvion, Mol. Biol. Cell, Nov 1998; 9: 3071.
Angelika Lueking, Mol. Cell. Proteomics, Dec 2003; 2: 1342.
Jason Fontana Circ, Res., May 2002; 90: 866.

References:

appl_detail:

Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500

Datasheet PDF