Product Datasheet  
HSP90B (Ab-254) Antibody  
Catalog Number: 33117  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot: P08238
    NCBI Gene ID: 3326
  • Form of Antibody：  
  • Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Synthesized non-phosphopeptide derived from human HSP90B around the phosphorylation site of serine 254 (V-G-S(p)-D-E).
  • reactivity：  
  • Hu
  • appl_detail：  
  • Western blotting: 1:500~1:3000
    Immunohistochemistry: 1:50~1:100
    Immunofluorescence: 1:100~1:500
  • other_names：  
  • HS90B; HSP 84; HSP90-beta; HSP90AB1; HSPC2
  • Purification：  
  • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Specificity：  
  • The antibody detects endogenous levels of total HSP90B protein.
  • Applications：  
  • WB IHC IF
  • Background：  
  • Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

    Lothar Goretzki, AACR Meeting Abstracts, Apr 2006; 2006: 468.
    Jean-Fran?ois Louvion, Mol. Biol. Cell, Nov 1998; 9: 3071.
    Angelika Lueking, Mol. Cell. Proteomics, Dec 2003; 2: 1342.
    Jason Fontana Circ, Res., May 2002; 90: 866.




 
© Signalway Biotechnology All Rights Reserved.