eLGALS3 Antibody

Catalog Number:

32285

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P17931
NCBI Gene ID:3958

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Recombinant protein of human LGALS3.

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total eLGALS3 protein.

Applications:

IHC,IF

Background:

Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of ¡Ò1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn¡¯s disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.

References:

appl_detail:

IHC 1:50 - 1:200
IF 1:20 - 1:50

Datasheet PDF