Product Datasheet  
eLGALS3 Antibody  
Catalog Number: 32285  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:P17931
    NCBI Gene ID:3958
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein of human LGALS3.
  • reactivity：  
  • Human,Rat
  • appl_detail：  
  • IHC 1:50 - 1:200
    IF 1:20 - 1:50
  • other_names：  
  • CBP35; GAL3; GALBP; GALIG; LGALS2
  • Purification：  
  • Antibodies were purified by affinity purification using immunogen.
  • Specificity：  
  • The antibody detects endogenous level of total eLGALS3 protein.
  • Applications：  
  • IHC,IF
  • Background：  
  • Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of ¡Ò1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn¡¯s disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.



 
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