BCL2L13 Antibody

Catalog Number:

32164

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9BXK5
NCBI Gene ID:23786

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Recombinant protein of human BCL2L13.

Purification:

Antibodies were purified by affinity purification using immunogen.

Specificity/Sensitivity:

The antibody detects endogenous level of total BCL2L13 protein.

Applications:

WB,IF

Background:

Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.

References:

appl_detail:

WB 1:500 - 1:2000
IF 1:20 - 1:50

Datasheet PDF