Product Datasheet  
BCL2L13 Antibody  
Catalog Number: 32164  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot:Q9BXK5
    NCBI Gene ID:23786
  • Form of Antibody：  
  • Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage：  
  • Store at -20˚C
  • Immunogen：  
  • Recombinant protein of human BCL2L13.
  • reactivity：  
  • Human
  • appl_detail：  
  • WB 1:500 - 1:2000
    IF 1:20 - 1:50
  • other_names：  
  • BCL2L13; MIL1; ProteinMil1; BCL-RAMBO; Bcl2-L-13
  • Purification：  
  • Antibodies were purified by affinity purification using immunogen.
  • Specificity：  
  • The antibody detects endogenous level of total BCL2L13 protein.
  • Applications：  
  • WB,IF
  • Background：  
  • Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.



 
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