NIPBL antibody

Catalog Number:

31986

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9UJD0
NCBI Protein#: BC033847

Form of Antibody:

pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Storage/Stability:

Immunogen:

Fusion protein of human NIPBL

Purification:

Antigen affinity purification

Specificity/Sensitivity:

Applications:

IHC

Background:

This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene.

References:

appl_detail:

IHC dilution:1:50-1:200

Datasheet PDF