Product Datasheet  
NIPBL antibody  
Catalog Number: 31986  
Technical:tech@swbio.com  
Information:info@swbio.com  
Description  
  • host_species：  
  • Rabbit
  • Amount：  
  • 100μgμg
  • Swiss-Prot No.：  
  • Swiss-Prot#: Q9UJD0
    NCBI Protein#: BC033847
  • Form of Antibody：  
  • pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • Storage：  
  • Store at -20˚C/1 year
  • Immunogen：  
  • Fusion protein of human NIPBL
  • reactivity：  
  • Hu, Ms
  • appl_detail：  

  • IHC dilution:1:50-1:200
  • other_names：  
  • CDLS; IDN3; Scc2; CDLS1; IDN3-B
  • Purification：  
  • Antigen affinity purification
  • Specificity：  
  • Applications：  
  • IHC
  • Background：  
  • This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene.



 
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